Hereditary asplenic-athymic mice: transplantation of human myelogenous leukemic cells

The hereditarily asplenic-athymic (lasat) mouse as an experimental animal model of lepromatous leprosy: role of the spleen in the formation of lepromatoid lesions.

Lozzio et al,(1,2) reported on the successful transplantation of human myelogenous leukemic cells by the use of the hereditarily asplenic-athymic (Lasat) mouse produced by mating the congenitally asplenic mouse impaired of its antibody production and the hereditarily athymic mouse deficient of its cellular immunity. On the other hand, we(3) reported hereditarily asplenic-athymic mouse by mating...

Development of myelosarcomas from human myelogenous leukemia cells transplanted in athymic mice.

Mice: Suppression by Antibody to Pluripotent K-562 Leukemia Cells Involves Direct Cytolysis and Effector Cells

Six human hematopoetic cell lines were successfully heterotransplanted into athymic (nude) and asplenic-athymic (Iasat) neonatal mice. The tumors arising from leukemia and lymphoma cells could then be serially transplanted into adult nude mice. Seven days after the fourth serial mouse passage, each mouse was treated with goat immune gamma globulin against K-562 cells. One control group was trea...

STAT5 is crucial to maintain leukemic stem cells in acute myelogenous leukemias induced by MOZ-TIF2.

MOZ-TIF2 is a leukemogenic fusion oncoprotein that confers self-renewal capability to hematopoietic progenitor cells and induces acute myelogenous leukemia (AML) with long latency in bone marrow transplantation assays. Here, we report that FLT3-ITD transforms hematopoietic cells in cooperation with MOZ-TIF2 in vitro and in vivo. Coexpression of FLT3-ITD confers growth factor independent surviva...

Proliferation of human malignant hematopoietic cells in immunodeficient mice: suppression by antibody to pluripotent K-562 leukemia cells involves direct cytolysis and effector cells.

Six human hematopoetic cell lines were successfully heterotransplanted into athymic (nude) and asplenic-athymic (lasat) neonatal mice. The tumors arising from leukemia and lymphoma cells could then be serially transplanted into adult nude mice. Seven days after the fourth serial mouse passage, each mouse was treated with goat immune gamma globulin against K-562 cells. One control group was trea...